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Oligodendrocytes are cells responsible for, among other things: protecting neurons -
Their damage can lead to serious neurological disorders, including multiple sclerosis — a chronic demyelinating disease that affects the central nervous system. -
Experts recommend monitoring the concentrations of these compounds in the bodies of adults and children and studying their effect on the risk of disease. -
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Not just genetics
Scientists from Case Western Reserve University (USA) warn against chemicals commonly used in homes. The compounds they identified may be linked to serious neurological disorders such as multiple sclerosis and autism spectrum disorders. Researchers point out that genetics explains only part of the development of these diseases, and important causes may lie in environmental factors. The mentioned substances may damage oligodendrocytes, which are responsible for producing the protective covering of nerve cells.
“Loss of oligodendrocytes underlies multiple sclerosis and other neurological diseases. We have shown that specific chemicals found in everyday products can directly damage these cells. “This is a previously unknown risk factor for neurological diseases,” says Professor Paul Tesar, author of the study.
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More than 1.8 thousand were analyzed. Material
In studying the possible effect on the brain, scientists analyzed more than 1.8 thousand. Substances that may affect humans. It turns out Organophosphates, used in furniture and electronics as flame retardants, can prevent the maturation of these cells, while quaternary ammonium compounds, used in many disinfectants such as hand gels and wipes, can trigger their death. The researchers reached these conclusions after conducting a series of different experiments on cells and on a mouse model.
“We have found that oligodendrocytes are surprisingly sensitive to the effects of quaternary ammonium compounds and organophosphate flame retardants, while other cells do not show such sensitivity. Understanding the effect of these substances in humans may contribute to identifying the missing factor influencing the increased incidence of infection.” “A neurological disorder,” said published author Erin Cohen.
Experts stress the need to conduct more research to find out the relationship between these substances and brain health. They recommend monitoring the concentrations of these compounds in the bodies of adults and children and studying their effect on the risk of disease.
“Our results suggest that a more comprehensive investigation into the impact of these commonly used household substances on the brain is necessary. We hope that our work will contribute to better decisions regarding regulations and legal behaviors aimed at reducing exposure and protecting health.” Professor Kaiser said.
Paul Carpenter — Professor of Neuroscience from the Department of Genetics and Genomic Sciences at Case Western Reserve University School of Medicine (USA).
Erin Cohen – Doctoral student at Case Western Reserve University School of Medicine.
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